human RPS6KA3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RPS6KA3.
shAAV-221935
AAV-h-RPS6KA3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RPS6KA3 (ribosomal protein S6 kinase A3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
90 kDa ribosomal protein S6 kinase 3; CLS; epididymis secretory sperm binding protein; HU-3; insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK1B; MAPKAPK-1b; MRX19; p90-RSK 3; p90-RSK2; p90RSK3; pp90RSK2; ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; ribosomal S6 kinase 2; RSK; RSK2; RSK-2; S6K-alpha3; S6K-alpha-3
Description (eCommerce)
Ribosomal protein S6 kinase alpha-2 (RSK2) is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. RSK2 kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome [taken from NCBI Entrez Gene (GeneID: 6197)].
Description (Vector)
RPS6KA3 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
Gene ID
6197
Gene Name (eCommerce)
ribosomal protein S6 kinase A3
Gene Name (Vector)
ribosomal protein S6 kinase A3
Gene Symbol
RPS6KA3
HGNC ID
HGNC:10432
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2223
ORF Size (bp)
2223 bp
Protein Name (eCommerce)
Ribosomal protein S6 kinase alpha-3
RefSeq ID
NM_004586
RefSeq Synonyms
NM_004586, BC096303, BC096302, BC096301,
Research Areas
Apoptosis,Axon Guidance,BDNF Signaling,Cell Cycle,EGFR Signaling,EPO Signaling,GPCR Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,MAPK Signaling,Meiosis,mTOR Signaling,Neurobiology,Neurodevelopment,NGF Signaling,PDGF Signaling,SCF-KIT Signaling,Signal Transduction,Toll-like Receptor Signaling,Transcription Factor/Regulator,Translational Control,VEGF Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Ribosomal protein S6 kinase alpha-2 (RSK2) is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. RSK2 kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome [taken from NCBI Entrez Gene (GeneID: 6197)].
UniGene ID
Hs.445387
UniProt ID (eCommerce)
P51812
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.