human RPS6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RPS6.
shAAV-221927
AAV-h-RPS6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RPS6 (ribosomal protein S6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
40S ribosomal protein S6; phosphoprotein NP33; S6; small ribosomal subunit protein eS6
Description (eCommerce)
Ribosomal protein S6 (RPS6) is a component of the 40S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis. RPS6 is phosphorylated by many cellular kinases including ribosomal protein S6 kinase that is regulated via the mammalian target of rapamycin (mTOR) pathway. RPS6 has been demonstrated to be important in regulating cell size, glucose homeostasis, and translational control of mRNA.
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6194
Gene Name (eCommerce)
ribosomal protein S6
Gene Name (Vector)
ribosomal protein S6
Gene Symbol
RPS6
HGNC ID
HGNC:10429
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
750
Protein Name (eCommerce)
40S ribosomal protein S6
RefSeq ID
NM_001010
RefSeq Synonyms
NM_001010, BC094826, BC071908, BC071907, BC027620, BC013296, BC000524,
Research Areas
Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Cancer,Gene Expression,HIF-1 Signaling,Host-Virus Interactions,IFN Signaling,IGF-1 Signaling,Immunology,Insulin Signaling,Interleukin Signaling,Leptin Signaling,Metabolism/Metabolic Process,mRNA Binding,mTOR Signaling,Neurobiology,Phospho-specific,PI3K/Akt Signaling,Prolactin Signaling,RNA Processing,SCF-KIT Signaling,Signal Transduction,Translational Control,TSH Signaling,TSLP Signaling
Research Areas (Faceted)
cancer,cell_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Ribosomal protein S6 (RPS6) is a component of the 40S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis. RPS6 is phosphorylated by many cellular kinases including ribosomal protein S6 kinase that is regulated via the mammalian target of rapamycin (mTOR) pathway. RPS6 has been demonstrated to be important in regulating cell size, glucose homeostasis, and translational control of mRNA.
UniGene ID
Hs.408073
UniProt ID (eCommerce)
P62753
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.