human RPS19BP1 shRNA silencing AAV

Name
AAV-h-RPS19BP1-shRNA

Cat No
shAAV-221856

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RPS19BP1.

shAAV-221856

AAV-h-RPS19BP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPS19BP1 (ribosomal protein S19 binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

40S ribosomal protein S19-binding protein 1; active regulator of SIRT1; AROS; homolog of mouse S19 binding protein; RPS19-binding protein 1; S19BP

Description (eCommerce)

The protein active regulator of SIRT1, also known as Ribosomal Protein S19 Binding Protein 1, is a direct regulator of SIRT1. By enhancing SIRT1-mediated deacetylation of p53/TP53 this protein participates in the inhibition of p53/TP53-mediated transcriptional activity. Active regulator of SIRT1 is encoded for by the gene RPS19BP1, also known as AROS or S19BP [taken from UniProtKB (Entry: Q86WX3)].

Gene ID

91582

Gene Name (eCommerce)

ribosomal protein S19 binding protein 1

Gene Name (Vector)

ribosomal protein S19 binding protein 1

Gene Symbol

RPS19BP1

HGNC ID

HGNC:28749

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

411

ORF Size (bp)

411 bp

Protein Name (eCommerce)

Active regulator of SIRT1

RefSeq ID

NM_194326

RefSeq Synonyms

NM_194326, BC047711, BC037573,

Research Areas

Cell Biology

Research Areas (Faceted)

cell_biology

Species

human

Target Sentence

The protein active regulator of SIRT1, also known as Ribosomal Protein S19 Binding Protein 1, is a direct regulator of SIRT1. By enhancing SIRT1-mediated deacetylation of p53/TP53 this protein participates in the inhibition of p53/TP53-mediated transcriptional activity. Active regulator of SIRT1 is encoded for by the gene RPS19BP1, also known as AROS or S19BP [taken from UniProtKB (Entry: Q86WX3)].

UniGene ID

Hs.526933

UniProt ID (eCommerce)

Q86WX3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.