human RPL3 shRNA silencing AAV

Name 
AAV-h-RPL3-shRNA
Cat No 
shAAV-221664
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RPL3.

shAAV-221664
AAV-h-RPL3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPL3 (ribosomal protein L3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
60S ribosomal protein L3; ASC-1; HIV-1 TAR RNA-binding protein B; L3; large ribosomal subunit protein uL3; TARBP-B
Description (eCommerce)
The L3 protein is a component of the large subunit of cytoplasmic ribosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P39023].
Description (Vector)
Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6122
Gene Name (eCommerce)
ribosomal protein L3
Gene Name (Vector)
ribosomal protein L3
Gene Symbol
RPL3
HGNC ID
HGNC:10332
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
756
Protein Name (eCommerce)
60S ribosomal protein L3
RefSeq ID
NM_000967
RefSeq Synonyms
NM_001033853, NM_000967, BC107711, BC088373, BC063662, BC036582, BC015767, BC014017, BC013674, BC012786, BC012146, BC008492, BC008003, BC006483, BC004323, BC002408,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,RNA Binding,RNA Processing,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,transcription_translation
Species
human
Target Sentence
The L3 protein is a component of the large subunit of cytoplasmic ribosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P39023].
UniGene ID
Hs.119598
UniProt ID (eCommerce)
P39023

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.