human RPL18A shRNA silencing AAV

Name
AAV-h-RPL18A-shRNA

Cat No
shAAV-221614

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RPL18A.

shAAV-221614

AAV-h-RPL18A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPL18A (ribosomal protein L18a). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

60S ribosomal protein L18a; L18A; large ribosomal subunit protein eL20; ribosomal protein L18a-like protein

Description (eCommerce)

RPL18A/Ribosomal Protein L18a binds IPO9 with high affinityÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q02543].

Description (Vector)

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome.

Gene ID

6142

Gene Name (eCommerce)

ribosomal protein L18a

Gene Name (Vector)

ribosomal protein L18a

Gene Symbol

RPL18A

HGNC ID

HGNC:10311

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

531

Protein Name (eCommerce)

60S ribosomal protein L18a

RefSeq ID

NM_000980

RefSeq Synonyms

NM_000980, BC071920, BC066319, BC007512,

Research Areas

Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,RNA Binding,RNA Processing,Translational Control

Research Areas (Faceted)

cell_biology,genetics,infectious_disease,metabolism,transcription_translation

Species

human

Target Sentence

RPL18A/Ribosomal Protein L18a binds IPO9 with high affinityÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q02543].

UniGene ID

Hs.337766

UniProt ID (eCommerce)

Q02543

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.