human RNF7 shRNA silencing AAV

Name
AAV-h-RNF7-shRNA

Cat No
shAAV-221439

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RNF7.

shAAV-221439

AAV-h-RNF7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RNF7 (ring finger protein 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CKBBP1; ROC2; SAG

Description (Vector)

RNF7 is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene ID

9616

Gene Name (Vector)

ring finger protein 7

Gene Symbol

RNF7

HGNC ID

HGNC:10070

ORF Size (aa)

342

RefSeq ID

NM_014245

RefSeq Synonyms

NM_183237, NM_014245, NM_001201370, BC008627, BC005966,

Species

human

UniGene ID

Hs.134623

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.