human RIOK1 shRNA silencing AAV

Name 
AAV-h-RIOK1-shRNA
Cat No 
shAAV-221249
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RIOK1.

shAAV-221249
AAV-h-RIOK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RIOK1 (RIO kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AD034; bA288G3.1; RIO kinase 1; RIO1; RRP10; serine/threonine-protein kinase RIO1
Description (eCommerce)
RIO kinase 1 (RIOK1) is a member of the RIO family of atypical serine protein kinases first characterized in yeast. There are three RIO kinase subfamilies: RIO1, RIO2, and RIO3. RIOK1 and RIOK2 proteins are present in organisms from Archaea to humans. Studies of RIO kinases in yeast indicate that they play a role in ribosome biogenesis.
Description (Vector)
RIOK1 includes two alternatively spliced transcript variants, which encode different isoforms. The function of this gene has not been determined.
Gene ID
83732
Gene Name (eCommerce)
RIO kinase 1
Gene Name (Vector)
RIO kinase 1
Gene Symbol
RIOK1
HGNC ID
HGNC:18656
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1707
ORF Size (bp)
1707 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase RIO1
RefSeq ID
NM_031480
RefSeq Synonyms
NM_153005, NM_031480, BC006104,
Research Areas
Cell Cycle,Kinase/Phosphatase,RNA Processing,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
RIO kinase 1 (RIOK1) is a member of the RIO family of atypical serine protein kinases first characterized in yeast. There are three RIO kinase subfamilies: RIO1, RIO2, and RIO3. RIOK1 and RIOK2 proteins are present in organisms from Archaea to humans. Studies of RIO kinases in yeast indicate that they play a role in ribosome biogenesis.
UniGene ID
Hs.437474
UniProt ID (eCommerce)
Q9BRS2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.