human RHO shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RHO.
shAAV-221170
AAV-h-RHO-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RHO (rhodopsin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CSNBAD1; OPN2; RP4
Description (Vector)
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness.
Gene ID
6010
Gene Name (Vector)
rhodopsin
Gene Symbol
RHO
HGNC ID
HGNC:10012
ORF Size (aa)
1047
ORF Size (bp)
1047 bp
RefSeq ID
NM_000539
RefSeq Synonyms
NM_000539, BC112106, BC112104, BC111451,
Species
human
UniGene ID
Hs.247565
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.