human RHD shRNA silencing AAV

Name
AAV-h-RHD-shRNA

Cat No
shAAV-221164

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RHD.

shAAV-221164

AAV-h-RHD-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RHD (Rh blood group D antigen). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD240D; DIIIc; RH; RH30; Rh4; RHCED; RhDCw; RHDel; RHDVA(TT); RhII; RhK562-II; RhPI; RHPII; RHXIII

Description (Vector)

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

6007

Gene Name (Vector)

Rh blood group D antigen

Gene Symbol

RHD

HGNC ID

HGNC:10009

ORF Size (aa)

966

RefSeq ID

NM_016124

RefSeq Synonyms

NM_016124, NM_001282872, NM_001282871, NM_001282870, NM_001282869, NM_001282868, NM_001282867, NM_001127691, BC160075, BC139922,

Species

human

UniGene ID

Hs.647623

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.