human RGS5 shRNA silencing AAV

Name
AAV-h-RGS5-shRNA

Cat No
shAAV-221130

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RGS5.

shAAV-221130

AAV-h-RGS5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RGS5 (regulator of G-protein signaling 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129

Description (Vector)

RGS5 encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. RGS5 is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. RGS5 is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified.

Gene ID

8490

Gene Name (Vector)

regulator of G-protein signaling 5

Gene Symbol

RGS5

HGNC ID

HGNC:10001

ORF Size (aa)

546

RefSeq ID

NM_003617

RefSeq Synonyms

NM_003617, NM_001254749, NM_001254748, NM_001195303, BC030059,

Species

human

UniGene ID

Hs.24950

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.