human RGS4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RGS4.
shAAV-221128
AAV-h-RGS4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RGS4 (regulator of G-protein signaling 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RGP4; SCZD9
Description (Vector)
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.
Gene ID
5999
Gene Name (Vector)
regulator of G-protein signaling 4
Gene Symbol
RGS4
HGNC ID
HGNC:10000
ORF Size (aa)
618
RefSeq ID
NM_005613
RefSeq Synonyms
NM_005613, NM_001113381, NM_001113380, NM_001102445, BC051869, BC000737,
Species
human
UniGene ID
Hs.386726
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.