human REL shRNA silencing AAV

Name 
AAV-h-REL-shRNA
Cat No 
shAAV-220992
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human REL.

shAAV-220992
AAV-h-REL-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human REL (REL proto-oncogene, NF-kB subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C-Rel; oncogene REL, avian reticuloendotheliosis; proto-oncogene c-Rel; v-rel avian reticuloendotheliosis viral oncogene homolog
Description (eCommerce)
c-Rel is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD). c-Rel was originally identified as the cellular version of the v-Rel oncogene derived from the avian reticuloendotheliosis retrovirus.
Description (Vector)
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 (PubMed 18037997)).(supplied by OMIM, May 2008)
Gene ID
5966
Gene Name (eCommerce)
REL proto-oncogene, NF-kB subunit
Gene Name (Vector)
REL proto-oncogene, NF-kB subunit
Gene Symbol
REL
HGNC ID
HGNC:9954
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1764
ORF Size (bp)
1764 bp
Protein Name (eCommerce)
Proto-oncogene c-Rel
RefSeq ID
NM_002908
RefSeq Synonyms
NM_002908, NM_001291746, BC143885, BC117191,
Research Areas
B-cell Receptor Signaling,Cancer,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,Leptin Signaling,NF-kB Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
c-Rel is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD). c-Rel was originally identified as the cellular version of the v-Rel oncogene derived from the avian reticuloendotheliosis retrovirus.
UniGene ID
Hs.631886
UniProt ID (eCommerce)
Q04864

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.