human RBL1 shRNA silencing AAV

107 kDa retinoblastoma-associated protein; CP107; p107; PRB1; retinoblastoma-like 1; retinoblastoma-like protein 1

Retinoblastoma-like protein 1 (RBL1) is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. RBL1 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. RBL1 probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It is a potent inhibitor of E2F-mediated trans-activation. RBL1 forms a complex with adenovirus E1A and with SV40 large T antigen and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RBL1 may act as a tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P28749].

RBL1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

5933

RB transcriptional corepressor like 1

RB transcriptional corepressor like 1

RBL1

HGNC:9893

9606.0

3045

3045 bp

Retinoblastoma-like protein 1

NM_002895

NM_183404, NM_002895, NM_001323282, NM_001323281, BC032247,

Cancer,Cell Cycle,Gene Expression,Host-Virus Interactions,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Viral Carcinogenesis

cancer,signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,signal_transduction,immunology,genetics,transcription_translation,cancer,cancer,infectious_disease

human

Retinoblastoma-like protein 1 (RBL1) is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. RBL1 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. RBL1 probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It is a potent inhibitor of E2F-mediated trans-activation. RBL1 forms a complex with adenovirus E1A and with SV40 large T antigen and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RBL1 may act as a tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P28749].

Hs.617220

P28749