human RBBP7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RBBP7.
shAAV-220832
AAV-h-RBBP7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RBBP7 (RB binding protein 7, chromatin remodeling factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
G1/S transition control protein-binding protein RbAp46; histone acetyltransferase type B subunit 2; histone-binding protein RBBP7; nucleosome-remodeling factor subunit RBAP46; RbAp46; RBBP-7; retinoblastoma-binding protein 7; retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46
Description (eCommerce)
Retinoblastoma-binding protein 7 (RbBP7) is a component of several complexes that regulate chromatin remodeling and assembly. RbBP7 is a subunit of the histone acetyltransferase (HAT) complex and of the core mSin3 histone deacetylase (HDAC) complex. RbBP7 is a histone binding subunit that functions to recruit chromatin assembly and remodeling factors to histones. RbBP7 also interacts with pRb and BRCA1 to modulate their activity.
Description (Vector)
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
5931
Gene Name (eCommerce)
RB binding protein 7, chromatin remodeling factor
Gene Name (Vector)
RB binding protein 7, chromatin remodeling factor
Gene Symbol
RBBP7
HGNC ID
HGNC:9890
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1278
ORF Size (bp)
1278 bp
Protein Name (eCommerce)
Histone-binding protein RBBP7
RefSeq ID
NM_002893
RefSeq Synonyms
NM_002893, NM_001198719, BC114501, BC114500,
Research Areas
Cell Cycle,Chromatin Remodeling,Complexome,DNA Replication,EGFR Signaling,Epigenetic Regulation of Gene Expression,Hedgehog Signaling,Polycomb Proteins,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Retinoblastoma-binding protein 7 (RbBP7) is a component of several complexes that regulate chromatin remodeling and assembly. RbBP7 is a subunit of the histone acetyltransferase (HAT) complex and of the core mSin3 histone deacetylase (HDAC) complex. RbBP7 is a histone binding subunit that functions to recruit chromatin assembly and remodeling factors to histones. RbBP7 also interacts with pRb and BRCA1 to modulate their activity.
UniGene ID
Hs.495755
UniProt ID (eCommerce)
Q16576
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.