human RBBP6 shRNA silencing AAV

Name 
AAV-h-RBBP6-shRNA
Cat No 
shAAV-220831
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RBBP6.

shAAV-220831
AAV-h-RBBP6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RBBP6 (RB binding protein 6, ubiquitin ligase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E3 ubiquitin-protein ligase RBBP6; MY038; P2P-R; p53-associated cellular protein of testis; PACT; proliferation potential-related protein; protein P2P-R; RB-binding Q-protein 1; RBQ-1; retinoblastoma binding protein 6; retinoblastoma-binding protein 6; retinoblastoma-binding Q protein 1; RING-type E3 ubiquitin transferase RBBP6; SNAMA
Description (eCommerce)
Retinoblastoma-binding protein 6 (RBBP6) is an E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). RBBP3 may play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53. It may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z6E9].
Description (Vector)
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.
Gene ID
5930
Gene Name (eCommerce)
RB binding protein 6, ubiquitin ligase
Gene Name (Vector)
RB binding protein 6, ubiquitin ligase
Gene Symbol
RBBP6
HGNC ID
HGNC:9889
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5379
ORF Size (bp)
5379 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase RBBP6
RefSeq ID
NM_006910
RefSeq Synonyms
NM_032626, NM_018703, NM_006910, BC172357, BC029352,
Research Areas
Cytoskeleton,Zinc-finger
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Retinoblastoma-binding protein 6 (RBBP6) is an E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). RBBP3 may play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53. It may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z6E9].
UniGene ID
Hs.188553
UniProt ID (eCommerce)
Q7Z6E9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.