human RB1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RB1.
shAAV-220819
AAV-h-RB1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RB1 (RB transcriptional corepressor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p105-Rb; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; RB; retinoblastoma 1; retinoblastoma suspectibility protein; retinoblastoma-associated protein
Description (eCommerce)
Retinoblastoma 1 (Rb1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. Rb1 has also been found to stabilize constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma [taken from NCBI Entrez Gene (GeneID: 5925)].
Description (Vector)
RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Gene ID
5925
Gene Name (eCommerce)
RB transcriptional corepressor 1
Gene Name (Vector)
RB transcriptional corepressor 1
Gene Symbol
RB1
HGNC ID
HGNC:9884
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2787
ORF Size (bp)
2787 bp
Protein Name (eCommerce)
Retinoblastoma-associated protein
RefSeq ID
NM_000321
RefSeq Synonyms
NM_000321, BC040540, BC039060,
Research Areas
Apoptosis,Autophagy,B-cell Receptor Signaling,Bladder Cancer,Breast Cancer,Cancer,CD95/FAS Signaling,Cell Cycle,Cell Division,Chromatin Remodeling,DNA Damage/Repair,DNA Replication,Glioma,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,Leukemia,Lung Cancer,Neurobiology,Neurodevelopment,p53 Signaling,Prolactin Signaling,Prostate Cancer,Signal Transduction,TGF-beta Signaling,TNF Signaling,Transcription Factor/Regulator,TSH Signaling,Tumor Suppressors/Oncoproteins,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Retinoblastoma 1 (Rb1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. Rb1 has also been found to stabilize constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma [taken from NCBI Entrez Gene (GeneID: 5925)].
UniGene ID
Hs.408528
UniProt ID (eCommerce)
P06400
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.