human RAPGEF5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RAPGEF5.
shAAV-220736
AAV-h-RAPGEF5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RAPGEF5 (Rap guanine nucleotide exchange factor 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GFR; MR-GEF; REPAC
Description (Vector)
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).(supplied by OMIM, Mar 2008)
Gene ID
9771
Gene Name (Vector)
Rap guanine nucleotide exchange factor 5
Gene Symbol
RAPGEF5
HGNC ID
HGNC:16862
ORF Size (aa)
1335
ORF Size (bp)
1335 bp
RefSeq ID
NM_012294
RefSeq Synonyms
NM_012294, BC039203,
Species
human
UniGene ID
Hs.713217
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.