human RALY shRNA silencing AAV

Name 
AAV-h-RALY-shRNA
Cat No 
shAAV-220687
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RALY.

shAAV-220687
AAV-h-RALY-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RALY (RALY heterogeneous nuclear ribonucleoprotein). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
autoantigen p542; heterogeneous nuclear ribonucleoprotein C-like 2; hnRNP associated with lethal yellow protein homolog; hnRNP core protein C-like 2; HNRPCL2; P542; RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog); RNA-binding protein (autoantigenic); RNA-binding protein (autoantigenic, hnRNP-associated with lethal yellow); RNA-binding protein RalY
Description (eCommerce)
The agouti (a) locus includes the mouse agouti gene that regulates coat color in mice by controlling the relative amount and distribution of yellow and black pigment in the coat hairs. A mutation in the agouti locus, lethal yellow (Ay), results in an all-yellow coat color along with a number of dominant pleiotropic effects such as obesity, diabetes, tumor susceptibility, and embryonic lethality in homozygotes. Molecular analysis of the Ay transcript revealed that the Ay transcript includes the coding region of the a gene but also included novel sequence. The novel sequence was found to originate from a 5’-noncoding exon of a gene that was named Raly, because it had the potential to encode an hnRNP protein that is associated with lethal yellow.
Description (Vector)
RALY encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants.
Gene ID
22913
Gene Name (eCommerce)
RALY heterogeneous nuclear ribonucleoprotein
Gene Name (Vector)
RALY heterogeneous nuclear ribonucleoprotein
Gene Symbol
RALY
HGNC ID
HGNC:15921
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
921
Protein Name (eCommerce)
RNA-binding protein Raly
RefSeq ID
NM_016732
RefSeq Synonyms
NM_016732, NM_007367, BC105018, BC103753,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
The agouti (a) locus includes the mouse agouti gene that regulates coat color in mice by controlling the relative amount and distribution of yellow and black pigment in the coat hairs. A mutation in the agouti locus, lethal yellow (Ay), results in an all-yellow coat color along with a number of dominant pleiotropic effects such as obesity, diabetes, tumor susceptibility, and embryonic lethality in homozygotes. Molecular analysis of the Ay transcript revealed that the Ay transcript includes the coding region of the a gene but also included novel sequence. The novel sequence was found to originate from a 5’-noncoding exon of a gene that was named Raly, because it had the potential to encode an hnRNP protein that is associated with lethal yellow.
UniGene ID
Hs.136947
UniProt ID (eCommerce)
Q9UKM9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.