human RAF1 shRNA silencing AAV

Cat. No: shAAV-220669

Availability: 4-5 weeks

Name: AAV-h-RAF1-shRNA

This is an AAV expressing shRNA for silencing of Human RAF1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RAF1
Gene Name: Raf-1 proto-oncogene, serine/threonine kinase
Gene ID: 5894
Gene Synonyms: c-Raf; CMD1NN; CRAF; NS5; Raf-1
ORF Size: 1947 bp
RefSeq#: NM_002880
Gene Description: RAF1 is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
UniGene ID: Hs.159130
HGNC ID: HGNC:9829