human RAB8A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RAB8A.
shAAV-220593
AAV-h-RAB8A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RAB8A (RAB8A, member RAS oncogene family). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MEL; RAB8
Description (Vector)
RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
Gene ID
4218
Gene Name (Vector)
RAB8A, member RAS oncogene family
Gene Symbol
RAB8A
HGNC ID
HGNC:7007
ORF Size (aa)
624
RefSeq ID
NM_005370
RefSeq Synonyms
NM_005370, BC002977,
Species
human
UniGene ID
Hs.642874
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.