human PTPRN shRNA silencing AAV

Name
AAV-h-PTPRN-shRNA

Cat No
shAAV-220354

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PTPRN.

shAAV-220354

AAV-h-PTPRN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPRN (protein tyrosine phosphatase, receptor type N). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N

Description (Vector)

PTPRN is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

Gene ID

5798

Gene Name (Vector)

protein tyrosine phosphatase, receptor type N

Gene Symbol

PTPRN

HGNC ID

HGNC:9676

ORF Size (aa)

2853

ORF Size (bp)

2853 bp

RefSeq ID

NM_002846

RefSeq Synonyms

NM_002846, NM_001199764, NM_001199763, BC070053, BC007713,

Species

human

UniGene ID

Hs.89655

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.