human PTPRE shRNA silencing AAV

Name
AAV-h-PTPRE-shRNA

Cat No
shAAV-220342

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PTPRE.

shAAV-220342

AAV-h-PTPRE-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPRE (protein tyrosine phosphatase, receptor type E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HPTPE; PTPE; R-PTP-EPSILON

Description (Vector)

PTPRE is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.

Gene ID

5791

Gene Name (Vector)

protein tyrosine phosphatase, receptor type E

Gene Symbol

PTPRE

HGNC ID

HGNC:9669

ORF Size (aa)

2103

ORF Size (bp)

2103 bp

RefSeq ID

NM_006504

RefSeq Synonyms

NM_130435, NM_006504, NM_001323357, NM_001323356, NM_001323355, NM_001323354, NM_001316677, NM_001316676, BC050062,

Species

human

UniGene ID

Hs.127022

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.