human PTPN6 shRNA silencing AAV

HCP; HCPH; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; PTP-1C; SHP1; SHP-1; SHP-1L; SH-PTP1; tyrosine-protein phosphatase non-receptor type 6

PTPN6/SHP-1 modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, SHP-1 induces UBE2V2 expression upon angiotensin II stimulation.SHP-1 plays a key role in hematopoiesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P29350].

PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

5777

protein tyrosine phosphatase, non-receptor type 6

protein tyrosine phosphatase, non-receptor type 6

PTPN6

HGNC:9658

9606.0

1794

1794 bp

Tyrosine-protein phosphatase non-receptor type 6

NM_002831

NM_080549, NM_080548, NM_002831, BC007667, BC002523,

Apoptosis,B-cell Receptor Signaling,Cancer,Cardiovascular,Cell Cycle,Cytokine Signaling,EGFR Signaling,EPO Signaling,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Phosphatase,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Translational Control,VEGF Signaling

cardiovascular,cancer,signal_transduction,cell_biology,immunology,cell_biology,cell_cycle,signal_transduction,immunology,signal_transduction,cell_biology,stem_cell_biology,signal_transduction,immunology,genetics,transcription_translation

human

PTPN6/SHP-1 modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, SHP-1 induces UBE2V2 expression upon angiotensin II stimulation.SHP-1 plays a key role in hematopoiesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P29350].

Hs.63489

P29350