human PTPN18 shRNA silencing AAV

Name
AAV-h-PTPN18-shRNA

Cat No
shAAV-220313

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PTPN18.

shAAV-220313

AAV-h-PTPN18-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPN18 (protein tyrosine phosphatase, non-receptor type 18). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BDP1; PTP-HSCF

Description (Vector)

PTPN18 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

26469

Gene Name (Vector)

protein tyrosine phosphatase, non-receptor type 18

Gene Symbol

PTPN18

HGNC ID

HGNC:9649

ORF Size (aa)

1056

ORF Size (bp)

1056 bp

RefSeq ID

NM_014369

RefSeq Synonyms

NM_014369, NM_001142370, BC052800,

Species

human

UniGene ID

Hs.591549

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.