human PTGES shRNA silencing AAV

Name
AAV-h-PTGES-shRNA

Cat No
shAAV-220244

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PTGES.

shAAV-220244

AAV-h-PTGES-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTGES (prostaglandin E synthase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1; PGES; PIG12; PP102; PP1294; TP53I12

Description (Vector)

PTGES is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Gene ID

9536

Gene Name (Vector)

prostaglandin E synthase

Gene Symbol

PTGES

HGNC ID

HGNC:9599

ORF Size (aa)

459

RefSeq ID

NM_004878

RefSeq Synonyms

NM_004878, BC008280,

Species

human

UniGene ID

Hs.146688

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.