human PTGER4 shRNA silencing AAV

Name
AAV-h-PTGER4-shRNA

Cat No
shAAV-220242

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PTGER4.

shAAV-220242

AAV-h-PTGER4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTGER4 (prostaglandin E receptor 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EP4; EP4R

Description (Vector)

PTGER4 is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Gene ID

5734

Gene Name (Vector)

prostaglandin E receptor 4

Gene Symbol

PTGER4

HGNC ID

HGNC:9596

ORF Size (aa)

1467

ORF Size (bp)

1467 bp

RefSeq ID

NM_000958

RefSeq Synonyms

NM_000958, BC113523, BC101534,

Species

human

UniGene ID

Hs.199248

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.