human PSMA5 shRNA silencing AAV

Name 
AAV-h-PSMA5-shRNA
Cat No 
shAAV-220102
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PSMA5.

shAAV-220102
AAV-h-PSMA5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PSMA5 (proteasome subunit alpha 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
epididymis tissue sperm binding protein Li 11n; macropain subunit zeta; macropain zeta chain; multicatalytic endopeptidase complex zeta chain; proteasome (prosome, macropain) subunit, alpha type, 5; proteasome alpha 5 subunit; proteasome component 5; proteasome subunit alpha type-5; proteasome subunit zeta; proteasome zeta chain; PSC5; ZETA
Description (eCommerce)
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSAM5 is member of the peptidase T1A family and is an alpha subunit of the 20S core [taken from NCBI Entrez Gene (GeneID: 5684)].
Description (Vector)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.
Gene ID
5686
Gene Name (eCommerce)
proteasome subunit alpha 5
Gene Name (Vector)
proteasome subunit alpha 5
Gene Symbol
PSMA5
HGNC ID
HGNC:9534
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
726
Protein Name (eCommerce)
Proteasome subunit alpha type-5
RefSeq ID
NM_002790
RefSeq Synonyms
NM_002790, NM_001199774, NM_001199773, NM_001199772, BC103751, BC102020, BC102019, BC102018,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,NF-kB Signaling,Notch Signaling,Proteasome,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,developmental_biology,cell_biology,genetics,transcription_translation,signal_transduction,immunology,genetics,developmental_biology
Species
human
Target Sentence
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSAM5 is member of the peptidase T1A family and is an alpha subunit of the 20S core [taken from NCBI Entrez Gene (GeneID: 5684)].
UniGene ID
Hs.712557
UniProt ID (eCommerce)
P28066

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.