human PSEN2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PSEN2.
shAAV-220068
AAV-h-PSEN2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PSEN2 (presenilin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; CMD1V; E5-1; presenilin-2; PS2; PS-2; STM2; STM-2
Description (eCommerce)
Presenilin-2 is a probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Presenilin-2 requires the other members of the gamma-secretase complex to have a protease activity. It may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may function in the cytoplasmic partitioning of proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49810].
Description (Vector)
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Gene ID
5664
Gene Name (eCommerce)
presenilin 2
Gene Name (Vector)
presenilin 2
Gene Symbol
PSEN2
HGNC ID
HGNC:9509
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1347
ORF Size (bp)
1347 bp
Protein Name (eCommerce)
Presenilin-2
RefSeq ID
NM_000447
RefSeq Synonyms
NM_012486, NM_000447, BC006365,
Research Areas
Alzheimer's Disease,Apoptosis,Brain Development,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Cell Cycle,Golgi Apparatus,Host-Virus Interactions,Hypoxia,Immunology,LKB1 Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Neurodevelopment,NGF Signaling,Notch Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Presenilin-2 is a probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Presenilin-2 requires the other members of the gamma-secretase complex to have a protease activity. It may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may function in the cytoplasmic partitioning of proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49810].
UniGene ID
Hs.25363
UniProt ID (eCommerce)
P49810
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.