human PRRG1 shRNA silencing AAV

Name
AAV-h-PRRG1-shRNA

Cat No
shAAV-220000

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PRRG1.

shAAV-220000

AAV-h-PRRG1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRRG1 (proline rich and Gla domain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PRGP1

Description (Vector)

PRRG1 encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. PRRG1 is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene.

Gene ID

5638

Gene Name (Vector)

proline rich and Gla domain 1

Gene Symbol

PRRG1

HGNC ID

HGNC:9469

ORF Size (aa)

657

RefSeq ID

NM_000950

RefSeq Synonyms

NM_001173490, NM_001173489, NM_001173486, NM_001142395, NM_000950, BC060833,

Species

human

UniGene ID

Hs.190341

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.