human PROZ shRNA silencing AAV

Name
AAV-h-PROZ-shRNA

Cat No
shAAV-219944

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PROZ.

shAAV-219944

AAV-h-PROZ-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PROZ (protein Z, vitamin K dependent plasma glycoprotein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Description (Vector)

PROZ encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.

Gene ID

8858

Gene Name (Vector)

protein Z, vitamin K dependent plasma glycoprotein

Gene Symbol

PROZ

HGNC ID

HGNC:9460

ORF Size (aa)

1203

ORF Size (bp)

1203 bp

RefSeq ID

NM_003891

RefSeq Synonyms

NM_003891, NM_001256134, BC074907, BC074906,

Species

human

UniGene ID

Hs.1011

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.