human PRDX3 shRNA silencing AAV

Name
AAV-h-PRDX3-shRNA

Cat No
shAAV-219772

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PRDX3.

shAAV-219772

AAV-h-PRDX3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRDX3 (peroxiredoxin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

antioxidant protein 1; AOP1; AOP-1; epididymis secretory sperm binding protein; HBC189; MER5; peroxiredoxin III; Peroxiredoxin-3; PRO1748; protein MER5 homolog; prx-III; SP-22; thioredoxin-dependent peroxide reductase, mitochondrial

Description (eCommerce)

Peroxiredoxin-3 (PRDX3) is involved in redox regulation of the cell [taken from NCBI Entrez Gene (Gene ID: 10935)].

Description (Vector)

PRDX3 encodes a protein with antioxidant function and is localized in the mitochondrion. PRDX3 shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.

Gene ID

10935

Gene Name (eCommerce)

peroxiredoxin 3

Gene Name (Vector)

peroxiredoxin 3

Gene Symbol

PRDX3

HGNC ID

HGNC:9354

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

771

Protein Name (eCommerce)

Thioredoxin-dependent peroxide reductase, mitochondrial

RefSeq ID

NM_006793

RefSeq Synonyms

NM_014098, NM_006793, NM_001302272, BC111397, BC059169, BC022373, BC021691, BC009601, BC008435, BC007062, BC002685,

Research Areas

Apoptosis,Mitochondrion,Neurobiology,Neurodevelopment

Research Areas (Faceted)

cell_biology,developmental_biology,neurobiology

Species

human

Target Sentence

Peroxiredoxin-3 (PRDX3) is involved in redox regulation of the cell [taken from NCBI Entrez Gene (Gene ID: 10935)].

UniGene ID

Hs.523302

UniProt ID (eCommerce)

P30048

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.