human PPP2R3A shRNA silencing AAV

Name
AAV-h-PPP2R3A-shRNA

Cat No
shAAV-219656

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PPP2R3A.

shAAV-219656

AAV-h-PPP2R3A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PPP2R3A (protein phosphatase 2 regulatory subunit B”alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PPP2R3; PR130; PR72

Description (Vector)

PPP2R3A encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

5523

Gene Name (Vector)

protein phosphatase 2 regulatory subunit B''alpha

Gene Symbol

PPP2R3A

HGNC ID

HGNC:9307

ORF Size (aa)

3453

ORF Size (bp)

3453 bp

RefSeq ID

NM_002718

RefSeq Synonyms

NM_181897, NM_002718, NM_001190447, BC065531,

Species

human

UniGene ID

Hs.518155

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.