human POLL shRNA silencing AAV

Name 
AAV-h-POLL-shRNA
Cat No 
shAAV-219371
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human POLL.

shAAV-219371
AAV-h-POLL-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POLL (DNA polymerase lambda). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BETAN; DNA polymerase beta-2; DNA polymerase beta-N; DNA polymerase kappa; DNA polymerase lambda; Pol beta2; Pol Lambda; POLKAPPA; polymerase (DNA directed), lambda; polymerase (DNA) lambda
Description (eCommerce)
DNA polymerase lambda (pol lambda) is a DNA polymerase involved in base excision repair (BER). Pol lambda possesses terminal transferase and 5’-deoxyribose-5-phosphate lyase activity. These activities have been found to be coordinated by PCNA and replication protein A.
Description (Vector)
POLL encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described.
Gene ID
27343
Gene Name (eCommerce)
DNA polymerase lambda
Gene Name (Vector)
DNA polymerase lambda
Gene Symbol
POLL
HGNC ID
HGNC:9184
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
903
Protein Name (eCommerce)
DNA polymerase lambda
RefSeq ID
NM_013274
RefSeq Synonyms
NM_013274, NM_001308382, NM_001174085, NM_001174084, BC068529, BC003548,
Research Areas
DNA Damage/Repair,DNA Replication,Immunology
Research Areas (Faceted)
cell_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
DNA polymerase lambda (pol lambda) is a DNA polymerase involved in base excision repair (BER). Pol lambda possesses terminal transferase and 5’-deoxyribose-5-phosphate lyase activity. These activities have been found to be coordinated by PCNA and replication protein A.
UniGene ID
Hs.523230
UniProt ID (eCommerce)
Q9UGP5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.