human PNKP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PNKP.
shAAV-219288
AAV-h-PNKP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PNKP (polynucleotide kinase 3′-phosphatase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2'(3')-polynucleotidase; AOA4; bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; EIEE10; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); MCS; ZPNK; Polynucleotide 3'-phosphatase; Polynucleotide 5'-hydroxyl-kinase; Polynucleotide kinase-3'-phosphatase
Description (eCommerce)
Polynucleotide kinase 3’-phosphatase (PNK1) is both a 5’-DNA kinase and a 3’-DNA phosphatase that plays a role in DNA repair following radiation or oxidative damage. PNK1 has been reported to participate in the repair of DNA-double strand breaks via PARP-1-dependent nonhomologous end-joining.
Description (Vector)
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
Gene ID
11284
Gene Name (eCommerce)
polynucleotide kinase 3'-phosphatase
Gene Name (Vector)
polynucleotide kinase 3'-phosphatase
Gene Symbol
PNKP
HGNC ID
HGNC:9154
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1449
ORF Size (bp)
1449 bp
Protein Name (eCommerce)
Bifunctional polynucleotide phosphatase/kinase
RefSeq ID
NM_007254
RefSeq Synonyms
NM_007254, BC033822, BC002519,
Research Areas
DNA Damage/Repair,DNA Replication,Kinase/Phosphatase,Neurobiology
Research Areas (Faceted)
cell_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Polynucleotide kinase 3’-phosphatase (PNK1) is both a 5’-DNA kinase and a 3’-DNA phosphatase that plays a role in DNA repair following radiation or oxidative damage. PNK1 has been reported to participate in the repair of DNA-double strand breaks via PARP-1-dependent nonhomologous end-joining.
UniGene ID
Hs.78016
UniProt ID (eCommerce)
Q96T60
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.