human PMS1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PMS1.
shAAV-219279
AAV-h-PMS1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PMS1 (PMS1 homolog 1, mismatch repair system component). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HNPCC3; hPMS1; MLH2; PMSL1
Description (Vector)
PMS1 encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.
Gene ID
5378
Gene Name (Vector)
PMS1 homolog 1, mismatch repair system component
Gene Symbol
PMS1
HGNC ID
HGNC:9121
ORF Size (aa)
2010
ORF Size (bp)
2010 bp
RefSeq ID
NM_000534
RefSeq Synonyms
NM_001321051, NM_001321049, NM_001321048, NM_001321047, NM_001321046, NM_001321045, NM_001321044, NM_001289409, NM_001289408, NM_001128144, NM_001128143, NM_000534, BC096331, BC008410,
Species
human
UniGene ID
Hs.111749
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.