human PLK1 shRNA silencing AAV

Name
AAV-h-PLK1-shRNA

Cat No
shAAV-219210

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PLK1.

shAAV-219210

AAV-h-PLK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLK1 (polo like kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

cell cycle regulated protein kinase; PLK; PLK-1; polo (Drosophia)-like kinase; Polo-like kinase 1; serine/threonine-protein kinase 13; serine/threonine-protein kinase PLK1; STPK13

Description (eCommerce)

Polo-like kinase 1 (PLK1) activity is central to the progression through mitosis. PLK1 plays an essential role in spindle formation and chromosome segregation. Recent studies suggest that PLK1 is specifically involved in anaphase spindle elongation, Rho localization to the contractile ring and cytokinesis.

Gene ID

5347

Gene Name (eCommerce)

polo like kinase 1

Gene Name (Vector)

polo like kinase 1

Gene Symbol

PLK1

HGNC ID

HGNC:9077

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1812

ORF Size (bp)

1812 bp

Protein Name (eCommerce)

Serine/threonine-protein kinase PLK1

RefSeq ID

NM_005030

RefSeq Synonyms

NM_005030, BC014846, BC003002, BC002369,

Research Areas

Apoptosis,Breast Cancer,Cancer,Cell Cycle,Cell Division,Cytoskeleton,DNA Damage/Repair,EPO Signaling,FoxO Signaling,Golgi Apparatus,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Meiosis,PLK1 Signaling,Prostate Cancer,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling,VEGF Signaling

Research Areas (Faceted)

cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.592049

UniProt ID (eCommerce)

P53350

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.