human PLCZ1 shRNA silencing AAV

Name
AAV-h-PLCZ1-shRNA

Cat No
shAAV-219142

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PLCZ1.

shAAV-219142

AAV-h-PLCZ1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLCZ1 (phospholipase C zeta 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NYD-SP27; PLC-zeta-1; PLCzeta; SPGF17

Description (Vector)

PLCZ1 is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants.

Gene ID

89869

Gene Name (Vector)

phospholipase C zeta 1

Gene Symbol

PLCZ1

HGNC ID

HGNC:19218

ORF Size (aa)

1248

ORF Size (bp)

1248 bp

RefSeq ID

NM_033123

RefSeq Synonyms

NM_033123, NM_001330774, NM_001330769, BC125067,

Species

human

UniGene ID

Hs.97542

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.