human PJA1 shRNA silencing AAV

Name
AAV-h-PJA1-shRNA

Cat No
shAAV-219016

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PJA1.

shAAV-219016

AAV-h-PJA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PJA1 (praja ring finger ubiquitin ligase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PRAJA1; RNF70

Description (Vector)

PJA1 encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. PJA1 is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants.

Gene ID

64219

Gene Name (Vector)

praja ring finger ubiquitin ligase 1

Gene Symbol

PJA1

HGNC ID

HGNC:16648

ORF Size (aa)

1932

ORF Size (bp)

1932 bp

RefSeq ID

NM_022368

RefSeq Synonyms

NM_145119, NM_022368, NM_001032396, BC105053, BC105051, BC075803,

Species

human

UniGene ID

Hs.522679

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.