human PITX1 shRNA silencing AAV

Name 
AAV-h-PITX1-shRNA
Cat No 
shAAV-219005
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PITX1.

shAAV-219005
AAV-h-PITX1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PITX1 (paired like homeodomain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BFT; CCF; hindlimb expressed homeobox protein backfoot; Hindlimb-expressed homeobox protein backfoot; homeobox protein PITX1; LBNBG; paired-like homeodomain transcription factor 1; pituitary homeo box 1; pituitary homeobox 1; pituitary otx-related factor; POTX; PTX1
Description (eCommerce)
PITX1 is a homeobox-containing transcription factor involved in the development of many organs. PITX1 has been demonstrated to play a critical role in pituitary organogenesis and can stimulate transcription from most pituitary hormone promoters. PITX1 has also been shown to stimulate the leutinizing hormone (LH)-beta gene promoter and may serve an important role in reproductive gene expression.
Description (Vector)
PITX1 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
Gene ID
5307
Gene Name (eCommerce)
paired like homeodomain 1
Gene Name (Vector)
paired like homeodomain 1
Gene Symbol
PITX1
HGNC ID
HGNC:9004
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
945
ORF Size (bp)
945 bp
Protein Name (eCommerce)
Pituitary homeobox 1
RefSeq ID
NM_002653
RefSeq Synonyms
NM_002653, BC009412, BC003685,
Research Areas
Cancer,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
human
Target Sentence
PITX1 is a homeobox-containing transcription factor involved in the development of many organs. PITX1 has been demonstrated to play a critical role in pituitary organogenesis and can stimulate transcription from most pituitary hormone promoters. PITX1 has also been shown to stimulate the leutinizing hormone (LH)-beta gene promoter and may serve an important role in reproductive gene expression.
UniGene ID
Hs.84136
UniProt ID (eCommerce)
P78337

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.