human PINK1 shRNA silencing AAV

Name
AAV-h-PINK1-shRNA

Cat No
shAAV-218975

Availability
Immediate

This is an AAV expressing shRNA for silencing of Human PINK1.

shAAV-218975

AAV-h-PINK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PINK1 (PTEN induced putative kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BRPK; PARK6

Description (Vector)

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Gene ID

65018

Gene Name (Vector)

PTEN induced putative kinase 1

Gene Symbol

PINK1

HGNC ID

HGNC:14581

ORF Size (aa)

1746

ORF Size (bp)

1746 bp

RefSeq ID

NM_032409

RefSeq Synonyms

NM_032409, BC028215,

Species

human

UniGene ID

Hs.389171

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.