human PILRA shRNA silencing AAV

Name
AAV-h-PILRA-shRNA

Cat No
shAAV-218967

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PILRA.

shAAV-218967

AAV-h-PILRA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PILRA (paired immunoglobin like type 2 receptor alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FDF03

Description (Vector)

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Gene ID

29992

Gene Name (Vector)

paired immunoglobin like type 2 receptor alpha

Gene Symbol

PILRA

HGNC ID

HGNC:20396

ORF Size (aa)

681

ORF Size (bp)

681 bp

RefSeq ID

NM_013439

RefSeq Synonyms

NM_178273, NM_178272, NM_013439, BC017812,

Species

human

UniGene ID

Hs.444407

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.