human PIBF1 shRNA silencing AAV

Name
AAV-h-PIBF1-shRNA

Cat No
shAAV-218894

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PIBF1.

shAAV-218894

AAV-h-PIBF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PIBF1 (progesterone immunomodulatory binding factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

70

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C13orf24; centrosomal protein of 90 kDa; CEP90; JBTS33; PIBF; progesterone-induced-blocking factor 1

Description (eCommerce)

Progesterone-induced blocking factor (PIBF) was originally discovered as a progesterone-induced protein that mediates the immunological effects of progesterone. PIBF is produced in PR-positive lymphocytes in healthy pregnant woman. A decreased percentage of PIBF-positive lymphocytes in pregnant woman is associated with premature pregnancy termination. PIBF appears to exert its immunomodulatory and anti-abortive effects by altering cytokine production and regulating natural killer (NK) cell activity.

Gene ID

10464

Gene Name (eCommerce)

progesterone immunomodulatory binding factor 1

Gene Name (Vector)

progesterone immunomodulatory binding factor 1

Gene Symbol

PIBF1

HGNC ID

HGNC:23352

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2097

ORF Size (bp)

2097 bp

Protein Name (eCommerce)

Progesterone-induced-blocking factor 1

RefSeq ID

NM_006346

RefSeq Synonyms

NM_006346, BC051911, BC041806,

Research Areas

Cell Biology,Cytoskeleton

Research Areas (Faceted)

cell_biology

Species

human

Target Sentence

Progesterone-induced blocking factor (PIBF) was originally discovered as a progesterone-induced protein that mediates the immunological effects of progesterone. PIBF is produced in PR-positive lymphocytes in healthy pregnant woman. A decreased percentage of PIBF-positive lymphocytes in pregnant woman is associated with premature pregnancy termination. PIBF appears to exert its immunomodulatory and anti-abortive effects by altering cytokine production and regulating natural killer (NK) cell activity.

UniGene ID

Hs.441926

UniProt ID (eCommerce)

Q8WXW3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.