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human PHYH shRNA silencing AAV

Name 
AAV-h-PHYH-shRNA
Cat No 
shAAV-218866
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PHYH.

shAAV-218866
AAV-h-PHYH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PHYH (phytanoyl-CoA 2-hydroxylase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LN1; LNAP1; PAHX; PHYH1; RD
Description (Vector)
PHYH is a member of the PhyH family and encodes a peroxisomal protein that is involved in the alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Mutations in this gene have been associated with Refsum disease (RD) and deficient protein activity has been associated with Zellweger syndrome and rhizomelic chondrodysplasia punctata. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene ID
5264
Gene Name (Vector)
phytanoyl-CoA 2-hydroxylase
Gene Symbol
PHYH
HGNC ID
HGNC:8940
ORF Size (aa)
1017
ORF Size (bp)
1017 bp
RefSeq ID
NM_006214
RefSeq Synonyms
NM_006214, NM_001323084, NM_001323083, NM_001323082, NM_001323080, NM_001037537, BC029512,
Species
human
UniGene ID
Hs.498732

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.