human PHF17 shRNA silencing AAV

Name 
AAV-h-PHF17-shRNA
Cat No 
shAAV-218807
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human JADE1.

shAAV-218807
AAV-h-PHF17-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human JADE1 (jade family PHD finger 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
gene for apoptosis and differentiation in epithelia; jade family PHD finger protein 1; PHD finger protein 17; PHD protein Jade-1; PHF17; protein Jade-1
Description (eCommerce)
Gene for apoptosis and differentiation-1 (Jade-1) is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3, and is responsible for the bulk of histone H4 acetylation in vivo. As a transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Jade-1 also Promotes apoptosis and may act as a renal tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q6IE81].
Gene ID
79960
Gene Name (eCommerce)
jade family PHD finger 1
Gene Name (Vector)
jade family PHD finger 1
Gene Symbol
JADE1
HGNC ID
HGNC:30027
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1530
ORF Size (bp)
1530 bp
Protein Name (eCommerce)
Protein Jade-1
RefSeq ID
NM_024900
RefSeq Synonyms
NM_199320, NM_024900, NM_001287443, NM_001287442, NM_001287441, NM_001287440, NM_001287439, NM_001287437, BC032376,
Research Areas
Apoptosis,Histone Modification,Mitochondrion,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Gene for apoptosis and differentiation-1 (Jade-1) is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3, and is responsible for the bulk of histone H4 acetylation in vivo. As a transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Jade-1 also Promotes apoptosis and may act as a renal tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q6IE81].
UniGene ID
Hs.12420
UniProt ID (eCommerce)
Q6IE81

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.