human PHC2 shRNA silencing AAV

Name
AAV-h-PHC2-shRNA

Cat No
shAAV-218790

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PHC2.

shAAV-218790

AAV-h-PHC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PHC2 (polyhomeotic homolog 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EDR2; HPH2; PH2

Description (Vector)

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

1912

Gene Name (Vector)

polyhomeotic homolog 2

Gene Symbol

PHC2

HGNC ID

HGNC:3183

ORF Size (aa)

2493

ORF Size (bp)

2493 bp

RefSeq ID

NM_004427

RefSeq Synonyms

NM_198040, NM_004427, NM_001330488, BC144121, BC130630,

Species

human

UniGene ID

Hs.524271

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.