human PDZK1 shRNA silencing AAV

Name
AAV-h-PDZK1-shRNA

Cat No
shAAV-218579

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PDZK1.

shAAV-218579

AAV-h-PDZK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDZK1 (PDZ domain containing 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAP70; CLAMP; NHERF-3; NHERF3; PDZD1

Description (Vector)

PDZK1 encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

5174

Gene Name (Vector)

PDZ domain containing 1

Gene Symbol

PDZK1

HGNC ID

HGNC:8821

ORF Size (aa)

1560

ORF Size (bp)

1560 bp

RefSeq ID

NM_002614

RefSeq Synonyms

NM_002614, NM_001201326, NM_001201325, BC006518, BC006496,

Species

human

UniGene ID

Hs.444751

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.