human PDSS1 shRNA silencing AAV

Name
AAV-h-PDSS1-shRNA

Cat No
shAAV-218557

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PDSS1.

shAAV-218557

AAV-h-PDSS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDSS1 (decaprenyl diphosphate synthase subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

COQ1; COQ10D2; DPS; hDPS1; SPS; TPRT; TPT; TPT 1

Description (Vector)

PDSS1 is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency.

Gene ID

23590

Gene Name (Vector)

decaprenyl diphosphate synthase subunit 1

Gene Symbol

PDSS1

HGNC ID

HGNC:17759

ORF Size (aa)

921

ORF Size (bp)

921 bp

RefSeq ID

NM_014317

RefSeq Synonyms

NM_014317, NM_001321979, NM_001321978, BC063635,

Species

human

UniGene ID

Hs.558468

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.