human PDS5A shRNA silencing AAV

Name 
AAV-h-PDS5A-shRNA
Cat No 
shAAV-218555
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PDS5A.

shAAV-218555
AAV-h-PDS5A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDS5A (PDS5 cohesin associated factor A). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cell proliferation-inducing gene 54 protein; PDS5, regulator of cohesion maintenance, homolog A; PIG54; SCC112; SCC-112; sister chromatid cohesion protein 112; sister chromatid cohesion protein PDS5 homolog A
Description (eCommerce)
SCC-112, also known as Pds5A, interacts with the cohesin multisubunit complex that plays a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Pds5 is implicated to participate in both stabilization and destabilization of cohesion-mediated cohesion in mitotic chromosomes.
Description (Vector)
PDS5A binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
23244
Gene Name (eCommerce)
PDS5 cohesin associated factor A
Gene Name (Vector)
PDS5 cohesin associated factor A
Gene Symbol
PDS5A
HGNC ID
HGNC:29088
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4014
ORF Size (bp)
4014 bp
Protein Name (eCommerce)
Sister chromatid cohesion protein PDS5 homolog A
RefSeq ID
NM_001100399
RefSeq Synonyms
NM_001100400, NM_001100399, BC126225, BC114218, BC009650,
Research Areas
Cell Cycle,Cell Division,DNA Replication
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
SCC-112, also known as Pds5A, interacts with the cohesin multisubunit complex that plays a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Pds5 is implicated to participate in both stabilization and destabilization of cohesion-mediated cohesion in mitotic chromosomes.
UniGene ID
Hs.331431
UniProt ID (eCommerce)
Q29RF7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.