human PDGFA shRNA silencing AAV

Name
AAV-h-PDGFA-shRNA

Cat No
shAAV-218503

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PDGFA.

shAAV-218503

AAV-h-PDGFA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDGFA (platelet derived growth factor subunit A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PDGF-A; PDGF1

Description (Vector)

PDGFA is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.

Gene ID

5154

Gene Name (Vector)

platelet derived growth factor subunit A

Gene Symbol

PDGFA

HGNC ID

HGNC:8799

ORF Size (aa)

588

RefSeq ID

NM_033023

RefSeq Synonyms

NM_033023, NM_002607, BC146594, BC141593,

Species

human

UniGene ID

Hs.535898

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.