human PDE6B shRNA silencing AAV

Cat. No: shAAV-218483

Availability: 6-8 weeks

Name: AAV-h-PDE6B-shRNA

This is an AAV expressing shRNA for silencing of Human PDE6B.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDE6B
Gene Name: phosphodiesterase 6B
Gene ID: 5158
Gene Synonyms: CSNB3; CSNBAD2; PDEB; rd1; RP40
ORF Size: 2562 bp
RefSeq#: NM_000283
Gene Description: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.654544
HGNC ID: HGNC:8786